Referan is the brand name of Aniracetam, an ampakine nootropic drug. It helps to improve mental performance such as alertness, attention, focus, learning and memory. Referan is used to treat disorders in connection to the Central Nervous System. This is a synthetic drug that belongs to Racetam class.
Why is Referan prescribed?
- Referan helps to treat schizophrenia, stress, depression, sleep disorder, dementia, chronic fatigue, urinary incontinence and autism.
- It has been prescribed for anxiety and personality disorders
- This nootropic drug plays a vital role to treat behavioral and emotional disturbances.
- Referan decreases the symptoms of Parkinson’s disease and progressive supra nuclear palsy
- Referan treats cognitive impairment in patients who suffer from cerebrovascular disease such as Alzheimer’s disease
How does Referan work?
GABA Receptors: GABA (gamma-amino butyric acid) is responsible for the emotional, cognitive functions. An increased GABA function treats cognitive and anxiety ailments.
Dopamine Receptors: Referan reduces anxiety and improves socialization through interacting with dopamine. The drug increases dopamine release and helps in improving judgment capability and mood
Nicotinic Cholinergic Receptors: Referan acts as a positive modulator of Nicotinic receptors which is involved in interacting with acetylcholine, a neurotransmitter. It also increases acetylcholine release from the hippocampus of the brain, results in hiking the cholinergic neurotransmission.
Serotonin Receptors: Referan inhibits the serotonin breakdown by acting on serotonin receptors. Decreased anxiety, improved mood and boosted energy are attained by increased serotonin levels.
Adrenergic Receptors: Referan binding to AMPA receptors enhances the noradrenalin release from neurons. It brings out the mild stimulatory effects on the CNS.
Recommended Referan dosage
- Referan dose varies for each individual. However, the recommended Referan clinical dose is 1500 mg per day, divided in to 3 times. It is advised to start with low doses to get accompanied to the Racetam family nootropic drug.
- Patients suffer from Alzheimer’s disease and senile dementia are generally recommended for 1000-1500 mg per day either as a single dose or as two doses, 750 mg each.
- 250 mg thrice a day is recommended for the people suffering from anxiety, depression
- Children under 18 years are not recommended to consume Referan
It is quite important to take Referan on a full stomach. It is better to take the drug after a full meal. This makes proper absorption as it is fat-soluble and reduces the side effects of gastrointestinal issues. Referan has to be taken along with Choline source such as Citicoline/Alpha GPC in order to intensify the affirmative effects on mental performance. Referan has to be administered with precursors for the acetylcholine, a neurotransmitter. If the brain has insufficient acetylcholine, it may lead to brain fog, headaches and other negative effects.
The most common side effects noted by the users are anxiety, nausea, headache, dizziness, diarrhea, insomnia, pain, restlessness, itchiness, stomach ache, vertigo, changes in body temperature, fatigue.
Most of the reviews of Referan are positive. The users stated that Referan alleviates negative thoughts and ideas, keeps in the good mood, and works as a productivity booster. It gives many benefits to the brain, synaptic plasticity along with lesser side effects.